Details
Webinar Objectives
In this webinar we will take you through the recent findings of the PROP OA randomised controlled trial. The webinar will provide an overview of the:
– Rationale and need for need for the trial
– Content of the bracing intervention tested within the trial, and the control
– Clinical and cost effectiveness findings
– Overall interpretation of the trial, and discussion of next steps
Overview
In this webinar Professor Melanie Holden will take us through the PROP OA trial, share the key findings and talk about what is next.
The PROP OA randomised controlled trial (RCT) aimed to evaluate whether adding compartment specific knee bracing with an adherence intervention to advice, written information, and exercise instruction (AIE+B) is clinically and cost effective compared with AIE alone in people with knee osteoarthritis (OA).
It was a 12 month, multi-centre, two-arm, parallel-group, randomised (1:1), superiority trial, with a 9 month internal pilot. The setting of the trial was primary care and the community, and participants with clinically diagnosed knee OA were identified from general practices and community advertisements around four regions in England. In total, 466 participants were randomised. AIE was delivered within a single, in-person consultation by a trained physiotherapist.
Individuals randomised to AIE+B were additionally fitted with a patellofemoral, tibiofemoral unloading, or neutral stabilising knee brace, according to their predominant compartmental distribution of knee OA, and were offered a two-week follow-up consultation. Brief motivational interviewing with targeted text reminders supported brace adherence.
The primary outcome was the composite patient-reported Knee Osteoarthritis Outcomes Score at 6 months post randomisation. Key secondary outcomes were KOOS-5 at 3 and 12 months, KOOS subscale scores and pain on weight-bearing activity at 3, 6, and 12 months, and incremental cost effectiveness ratio (ICER) at 12 months.
PROP OA is registered with the ISRCTN registry (ISRCTN28555470) and is currently undergoing peer review for publication